Endocrine Abstracts

A 64 years old female presented with frontal headache and sinusitis like features. Later she got double vision when she woke up in the morning. No eye pain or vision loss. No weakness in the limbs. No neck pain. On examination: BP, heart rate and other observations within normal limits. No postural hypotension. Diplopia on left lateral gaze, very limited abduction of left eye. Other cranial nerves intact. Normal visual fields. No signs of Cushing’s. No motor or sensory de...

A 43 year old female experienced sudden sever back pain after lifting her baby’s buggy in January 2014. In October 2013, she had an emergency caesarean section to deliver her baby. This was performed for a prolonged first stage of labour with foetal distress. She breast fed her baby for 16 weeks. Her baby was conceived in early 2013 on the first attempt using donor egg and sperm. Her husband was found to have azoospermia. They therefore approached a Fertility Clinic and s...

Section 1: Case history: A 58 year old lady presented to the Emergency Department with a two week history of general lethargy, weight loss, increased thirst and polyuria as well as muscle cramps in her legs. Aside from sinus tachycardia, her observations and physical examination were unremarkable on admission. She had a background of hypertension on Indapamide as well as idiopathic hypoparathyroidism on Alfacalcidol. The latter had been diagnosed nine years prior following adm...

Case History: A 64 year old lady with osteoporosis was referred for parental antiresorptive therapy due to a history of oral bisphosphonate intolerance. She was screened for osteoporosis at age 53 after her mother suffered a hip fracture, DEXA showing an L2-L4 T score of −2.5 and mean femur −2.2. She was given a trial of alendronate, but stopped due to indigestion. On Calcium and Vitamin D supplementation, the DEXA after 4 years showed improvement of both the spine...

Case History: A 64 year old lady was referred for parental antiresorptive therapy due to a history of oral bisphosphonate intolerance. She had been screened for osteoporosis at age 53 after her mother had suffered a hip fracture, DEXA scan showed an L2-L4 T score of −2.5 and a mean femur −2.2. She was given a trial of alendronate, but had stopped due to indigestion. The DEXA scan at 4 years showed improvement of both the spine and femur densities on Calcium and Vit...

A 33 year-old-lady presented to the emergency department with acute abdominal pain and per vaginal bleeding. Her last menstrual period was six weeks prior to admission. She had a positive urine pregnancy test and a trans-vaginal ultrasound confirming an ectopic tubal pregnancy. She underwent an emergency laparoscopic right salpingectomy under general anaesthesia with blood loss intra-operatively of 300 ml. One day post-op, her haemoglobin dropped from 129 g/l to 86 g/l. She re...

A 26 year old man of Angolan descent presented to the endocrine clinic with poorly controlled hypertension (systolic blood pressure >200 mmHg). He had been treated with Amlodipine for almost six years, and more recently the addition of Irbesatan and Indapamide had not led to adequate blood pressure control. His hypertension was diagnosed at age 19 and progressive features of Cushing’s disease had remained unnoticed, with truncal striae, easy bruising, myopathy, puffin...

We present the case of a 32 year old woman presenting to her GP with right lower leg pain. This pain was worse at night, but responded to simple analgesia. She was initially diagnosed with arthritis but the leg pain worsened and became bilateral. She had no other significant past medical history with no history of fevers, trauma, fractures or dental problems. She had no relevant family, social or medication history.On examination, ...

We present the case of a 32 year old woman presenting to her GP with right lower leg pain. This pain was worse at night, but responded to simple analgesia. She was initially diagnosed with arthritis but the leg pain worsened and became bilateral. She had no other significant past medical history with no history of fevers, trauma, fractures or dental problems. She had no relevant family, social or medication history.On examination, ...

Introduction: Approximately 5-10% of PHPT cases are hereditary. One such hereditary cause of PHPT is Hyperparathyroidism-jaw Tumour Syndrome (HPT-JT) caused by an autosomal dominant mutation in cell division cycle 73 (CDC73) that impairs parafibromin, a protein with antiproliferative activity. HPT-JT is characterised by parathyroid tumours, ossifying jaw fibromas, renal tumours and uterine tumours. We report a familial case of HPT-JT caused by a novel CDC73 mutation.<...